A new Rab7 effector controls phosphoinositide conversion in endosome maturation
نویسندگان
چکیده
Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201705151) identify WDR91 as a ubiquitous Rab7 effector that inhibits phosphatidylinositol 3-kinase activity on endosomes and is critical for endosome maturation, viability, and dendrite growth of neurons in vivo.
منابع مشابه
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عنوان ژورنال:
دوره 216 شماره
صفحات -
تاریخ انتشار 2017